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Variants can result from DNA copying mistakes designed in the course of mobile division or particular environmental exposures. Variants that occur while in the egg or sperm (germline mutations) is often passed on to offspring, while variants that come about in other physique cells (somatic mutations) are not handed on.

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Some disorders, like several cancers, are a result of genetic variations that happen throughout anyone's lifetime. These are generally known as obtained or somatic mobile genetic modifications.

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